Gastroenterology and Hepatology

Genetic and Immunological Mechanisms in Autoimmune Gastrointestinal Disorders

Autoimmune gastrointestinal (GI) disorders, including conditions such as Celiac disease, Inflammatory Bowel Disease (IBD), and Autoimmune Hepatitis, result from the immune system mistakenly attacking the body’s own tissues. These diseases are characterized by chronic inflammation, mucosal damage, and impaired organ function. Understanding the genetic and immunological mechanisms that underlie these disorders is crucial for improving diagnosis, treatment, and patient outcomes.

Genetic susceptibility plays a significant role in the development of autoimmune GI disorders. Specific genetic variants, such as those found in the HLA (Human Leukocyte Antigen) region, have been strongly associated with conditions like Celiac disease and IBD. These genetic factors influence immune system activation, altering how the body responds to environmental triggers like infections or dietary factors.

This track will explore the latest discoveries in the genetic and immunological mechanisms driving autoimmune GI disorders. The goal is to enhance understanding of these conditions, identify novel therapeutic targets, and contribute to the development of more effective, personalized treatments for patients suffering from these chronic conditions.