Gastroenterology and Hepatology

Role of MicroRNAs in Genetic Regulation of Liver Diseases

MicroRNAs (miRNAs) are small, non-coding RNA molecules that play a crucial role in regulating gene expression at the post-transcriptional level. In the context of liver diseases, miRNAs are emerging as key regulators of various genetic pathways involved in disease progression, inflammation, fibrosis, and tumorigenesis. This track will focus on the growing body of research exploring the role of miRNAs in the genetic regulation of liver diseases such as Non-Alcoholic Fatty Liver Disease (NAFLD), cirrhosis, hepatitis, and hepatocellular carcinoma (HCC).

MiRNAs influence the expression of genes involved in critical processes such as cell proliferation, apoptosis, fibrosis, and immune response. Dysregulation of specific miRNAs has been linked to liver injury, fibrosis progression, and the development of liver cancer. For example, miR-122, a liver-specific miRNA, has been shown to regulate lipid metabolism and is a potential biomarker for liver disease progression.

This session will provide insights into the mechanisms by which miRNAs regulate liver disease pathways and their potential as biomarkers and therapeutic targets in liver disease management.