Gastroenterology and Hepatology

Immunology and Genetic Mechanisms in Liver Transplantation

Liver transplantation is a life-saving procedure for patients with end-stage liver diseases, but its success depends heavily on managing immune responses and understanding genetic factors. Immunology plays a central role in both the rejection of transplanted livers and the long-term survival of transplant recipients. The body's immune system recognizes the donor liver as foreign and may initiate an immune response, leading to acute or chronic rejection. This requires careful immunosuppressive therapy to prevent rejection while managing the risks of infection and malignancy.

Genetic factors, both in the donor and recipient, influence transplant outcomes. Genetic incompatibility between donor and recipient, particularly with human leukocyte antigens (HLA), can affect the likelihood of rejection. Research into genomic profiling is helping to identify patients at higher risk for rejection or graft failure, allowing for more personalized treatment strategies.

This track will delve into the latest advancements in the immunology and genetic mechanisms influencing liver transplantation, offering insights into improving graft survival, minimizing rejection, and advancing personalized care for transplant patients.